As a daily Kratom user, I would not recommend using Kratom for something like depression. You're treating the symptomps at best while cultivating addiction.
Yeah, always best to not fuck around with chemicals that bind to gabba receptors (alcohol, benzodiazepine, kratom). It will give you a hell of a withdrawal if you take high doses. This is why there are alcoholics.
Kratom binds primarily to mu-opioid receptors. It's a bit disingenuous to say it binds to gabba. I mean, I am sure it is true that some alkaloids in Kratom bind to gabba, but that's not the primary interaction.
